One of DIM’s primary effects involves the hormone estrogen. As we know, estrogen is important for both men and women, but too much of it can predispose to various cancers. For women, too much estrogen increases the risk for breast, ovarian, and endometrial cancers. For men, too much estrogen is believed to contribute to prostate cancer. Breast Cancer Prevention in a Pill BY CHRISTINE HORNER, M.D. Breast cancer is the most common form of cancer among American women and the second-leading cause of cancer-related deaths. The older a woman, the higher her risk. At age 25, her risk is 1 in 19,608. At age 40, 1 in 217. If she lives to be more than 85, her risk is 1 in 8.
In a RCT of estrogen receptor-positive breast cancer patients taking tamoxifen, daily DIM promoted an increase in the metabolite ratio of 2-hydroxyestrone (2-OHE1) (anti-tumorigenic) to 16α-hydroxyestrone (16α-OHE1) (pro-tumorigenic). However, this increase was coupled with a . Oct 30, 2013 · And there are several indications that DIM may suppress breast cancer cell growth. It inhibits the growth of at least 4 different lines of breast cancer cells, including some that lack estrogen receptors. It can decrease the activity of molecules that help plow through normal tissues so that metastases can settle. It sensitizes breast cancer cells to the.
Stop Breast Cancer with Supplements of DIM. They found that DIM significantly decreases several markers of inflammation, including the release of nitric oxide, prostaglandin E2, tumor necrosis factor alpha, interleukin-6 and IL-1beta cells. D iindolylmethane, better known as " DIM", is a potent anti-cancer and cancer-preventative compound found in many cruciferous vegetables, such as broccoli, cabbage, and kale. If you are battling an estrogen-sensitive cancer, such as an ER+ breast cancer, or are concerned with estrogen overload, pay close attention to this top supplement.
Mar 10, 2009 · Supplements of DIM Stop Many Cancers in Their Tracks. Incidence of breast cancer and other estrogen related cancers is low in societies that consume a diet high in total vegetable content. For those people, DIM is gotten by regularly eating broccoli, . May 16, 2019 · Diindolylmethane transduces signaling via aryl hydrocarbon (Ah) receptor, NF-κB/Wnt/Akt/mTOR pathways, to help inhibit growth. These pathways are typically up-regulated in cancer patients yet DIM may help block many of these avenues. DIM also was found to induce cell cycle arrest, helping slow replication of cancer cells.
Jul 12, 2011 · Diindolylmethane in Treating Patients With Breast Cancer. II. Evaluate the effect of an escalating daily dose of DIM on serum steroid hormones (estrogen, sex hormone binding globulin [SHBG]) and urinary 2-hydroxyestrone:16 alpha-hydroxyestrone (2OHE1:16 alpha OHE1) ratio as well as serum tamoxifen (TAM) metabolites (endoxifen). Apr 22, 2015 · Specific DIM Warnings and Precautions. In comparison, those who did not develop breast cancer had a high ratio of “good” estrogen metabolites to “bad” estrogen metabolites. Scientists have determined that DIM actually inhibits the growth of cancer cells. It enhances the activity of enzymes found in certain pathways of the liver.